SphK-S1P-S1PR信号通路在肿瘤发病机制中的作用

Roles of SphK-S1P-S1PR signaling pathway in pathogenesis of tumors

1-磷酸鞘氨醇（S1P）是一种具有生物活性的脂质信使，可由鞘氨醇激酶（SphX）催化产生，并作用于1-磷酸鞘氨醇受体（S1PR）介导多种生物学行为。研究表明，SphK、S1P及S1PR的异常与白血病、乳腺癌、结肠癌、淋巴瘤等的发生发展密切相关，S1PR1与信号转导及转录激活子3（STAT3）的相互作用也参与了恶性肿瘤的发病，因而具有潜在的肿瘤治疗价值。

Sphingosine-l-phosphate （S1 P） is a kind of bioactive messenger which is catalyzed by sphingosine kinases （SphK） and mediates various biological behaviors through binding to sphingosine-l-phos- phate receptors（S1PR）. Researches demonstrate that the aberration of SphK, S1P and S1PR is closely related to the occurrence and development of cancers, such as leukemia, breast cancer, colorectal cancer and lympho- ma. The interaction between S1PR1 and signal transducer and activator of transcription 3 （STA33） is shown to take part in the pathogenesis of malignant tumors as well. Therefore, they are considered to have the potential tumor-treatment value.