缺氧诱导因子-1α与上皮间质转化

Relationship between factor-1α and epithelial mesenchymai transformation

缺氧诱导因子-1α（HIF—1α）是一种细胞缺氧应答调控因子，在多种恶性肿瘤中呈高表达。研究表明，HIF-1α在上皮间质转化（EMT）过程中发挥重要作用，它可通过一系列信号通路及作用机制多方面、多层次地调控EMT的发生，参与肿瘤的侵袭和转移。探寻HIF-1α调控EMT相关机制对开发新的、有效的肿瘤治疗方法有重要意义。

Hypoxia inducible factor （HIF-1α） is a hypoxia response regulator, which is highly expressed in malignant tumors. Researches have shown that HIF-1α plays an important role in epithelial mesen- chymal transformation. It can regulate epithelial mesenehymal transition through a series of signal pathways and mechanisms at many levels, to participate in the invasion and metastasis of tumors. To explore the mechanism of HIF-1α controlling epithelial mesenchymal transformation has important significance for the development of new, effective tumor treatment methods.