精神分裂症共病代谢综合征患者血清同型半胱氨酸的对照研究

Serum Homocysteine Level in Schizophrenia with Metabolic Syndrome

目的对精神分裂症共病代谢综合征(MS)患者血清同型半胱氨酸(Hcy)水平进行对照研究。方法 33例首次确诊为MS的精神分裂症患者作为观察组,33例不伴有MS的精神分裂症患者作为对照组,分别测定其空腹血清Hcy水平;同时测定腰围、体质量指数(BMI)、空腹血糖(FBG)、血脂[总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、血压[收缩压(SBP)/舒张压(DBP)]等MS相关指标。结果①观察组血清Hcy水平显著高于对照组,两组比较差异有统计学意义(t=-2.775,P<0.01);②观察组高Hcy血症的发生率显著高于对照组,两组比较差异有统计学意义(χ2=6.061,P<0.05);③观察组的血清Hcy水平与HDL-C、LDL-C具有相关性(r=-0.346,0.373;P<0.05),而与腰围、BMI、FBG、TC、TG、SBP、DBP均无显著的相关;对照组的血清Hcy水平与腰围、BMI、FBG、TC、TG、HDL-C、LDL-C、SBP、DBP均无显著的相关性。结论与不伴发MS的精神分裂症患者相比,伴发MS的精神分裂症患者血清Hcy水平显著增高;伴发MS的精神分裂症患者的血清Hcy水平与HDL-C、LDL-C有关。

Objective To evaluate serum homocysteine level in schizophrenia patients with metabolic syndrome .Methods 33 schiz-ophrenia patients with first diagnosed metabolic syndrome as observation group and 33 schizophrenia patients without metabolic syndrome as control group,were measured serum homocysteine（Hcy）,subcomponents of metabolic syndrome （MS ）including waist circumference body mass index（BMI）,fasting plasma glucose（FPG）,blood fat[total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cho-lesterol（HDL-C）,low-density lipoprotein cholesterol （LDL-C）]and blood pressure[systolic blood pressure（SBP）/diastolic blood pressure（DBP）] for all subjects respectively.Results The level of serum homocysteine was found to be higher in observation group than in control group（t=-2.775,P〈0.01）.The prevalence of hyperhomocysteinemia in observation group was higher than that in control group（χ2 =6.061,P〈0.05）.In observation group serum homocysteine level was correlated with HDL -C、LDL-C （r =-0.346,P〈0.05;r=0.373,P〈0.05）,but was not correlated with waist circumference ,BMI,FBG,TC,TG,SBP,DBP（r=-0.265~0.344,all P〉0.05）;In control group serum homocysteine level was not correlated with waist circumference ,BMI,FBG,TC,TG,HDL-C,LDL-C, SBP,DBP.Conclusion Schizophrenia patients with metabolic syndrome have elevated serum homocysteine compared with schizophrenia patients without metabolic syndrome;In schizophrenia patients with metabolic syndrome ,serum homocysteine level is correlated with HDL-C and LDL-C.