创伤后应激障碍患者免疫水平的相关性

Correlation of Serum Immune Levels with Posttraumatic Stress Disorder

目的：探讨创伤后应激障碍（ PTSD）患者免疫功能的变化及其与PTSD患者病情严重程度的相关性。方法入组15例无躯体损伤的精神创伤后应激障碍患者[ PCL-C量表得分52～79分，平均（62±8）分]为实验组，15例经历精神创伤事件未发生创伤后应激障碍且PCL-C量表得分＜12分[（得分0～11分，平均（4±4）分]的预恢复人群（预恢复至常态/基本无症状）为对照组，两组均用酶联免疫吸附方法测定血清细胞因子（ IL-2、IL-6、IL-10、肿瘤坏死因子）水平，并分析其与PCL-C量表得分的相关性。结果实验组与对照组间非参数检验除白介素IL-2有显著性差异外（Z＝-2．780，P＝0．005），其余3项生物学指标差异均无显著性。实验组血清IL-2、IL-6、IL-10、肿瘤坏死因子水平与PCL-C量表得分无显著相关性。结论创伤后应激障碍患者白介素IL-2水平异常，其免疫学水平及相关性有待进一步研究。

Objective To explore the correlation of immune function on mental post-traumatic stress disorder patients with PTSD . Methods 15 cases of mental post-traumatic stress disorder patients with no body damage （ the patients＇PCL-C score was more than 50 points,scoring 52 points to 79 points,mean and standard deviation 62 ±8）as PTSD group and 15 cases of patients were undergo traumatic matters without PTSD（the patients＇PCL-C score was less than 12 points,scoring 0 points to 11 points,mean and standard deviation 4± 4）as control group were tested 4 serum cell factor（IL-2,IL-6,IL-10,tumor necrosis factor -α）with Enzyme-linked immunosorbent method.Results The level of interleukin IL -2 had significant difference between two groups （Z=-2.780,P=0.005）.There were no significant differences among the remaining three immune indicators （P〉0.05）.And there was no significant correlation between 4 im-mune indicators and scores of PCL -C in PTSD group either .Conclusion Biology level of interleukin IL -2 exists disorder on post -traumatic stress disorder patients ,immunology-level and its correlation with PTSD needs to be further researched .