摘要
Osteoarthritis （OA） is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro an, in vivo studies suggest that confirmed （TGF-β）/SMAD pathway plays a critical role during OA development This short review will focus on the function and signaling mechanisms of TGF-β/SMAD pathway in articula chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.
Osteoarthritis （OA） is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro an, in vivo studies suggest that confirmed （TGF-β）/SMAD pathway plays a critical role during OA development This short review will focus on the function and signaling mechanisms of TGF-β/SMAD pathway in articula chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.
基金
supported by Grants R01 AR055915 and R01 AR054465 to DC from the National Institute of Health
