青岛地区孕妇弓形虫感染调查

Investigation of Toxoplasma gondii infection in pregnant women in Qingdao area

目的：了解青岛地区孕妇弓形虫感染情况。方法2011年6月-2013年7月，对山东省青岛市妇女儿童医院进行产前检查并自愿接受弓形虫检测及就诊的不孕症、流产、死胎等异常妊娠孕妇，采用抗体捕获ELISA法进行弓形虫IgM、IgG抗体以及弓形虫DNA检测。结果异常妊娠与正常孕妇弓形虫抗体阳性率分别为22.39%和6.26%，差异有统计学意义（χ2=10.60，P＜0.05）。20～29岁与30岁以上人群阳性率差异有统计学意义（χ2=21.9，P＜0.05）。家中饲养与未饲养宠物孕妇弓形虫感染率分别为26.63%和8.77%，差异有统计学意义（χ2=10.93，P＜0.05）。无业人员阳性率最高，为10.94%（22/201），农民3.98%（8/201）次之，其他为职工3.98%（8/201）、工人3.48%（7/201）。结论青岛市异常妊娠孕妇的弓形虫感染率明显高于正常妊娠孕妇，应加强孕妇的健康教育以降低弓形虫感染的风险，对于特定年龄以及职业人群更要加强预防工作。

Objective To understand the status of Toxoplasma gondii（TOX）infection in pregnant women in Qingdao area. Methods Antibody capture ELISA was used to detect the TOX-IgM,IgG and TOX-DNA in 1 341 pregnant women and 201 infer-tility,miscarriage,stillbirth pregnant women from June 2011 to July 2013. Results Among 201 abnormal pregnant women,43 cases were TOX antibody positive,accounting for 22.39%,and among the normal pregnant women,84 cases were TOX antibody positive,accounting for 6.26%,and there was a significant difference（χ2 =10.60,P〈0.05）. The TOX positive rate of 20-29 years old women was higher than that of the women aged over 30 years（χ2=21.9,P〈0.05）. The TOX antibody positive rates of families with pets and families without pets were 26.63%and 8.77%respectively（χ2=10.93,P〈0.05）. The TOX antibody posi-tive rates were 10.94%（22/201）in unemployed women,3.98%（8/201）in farmers,3.98%（8/201）in staff,and 3.48%（7/201）in workers. Conclusions The TOX infection rate in abnormal pregnant women is significantly higher than that in normal pregnancy women;therefore,the health education should be strengthened. In addition,in young women,especially 20-29 years old women, and some special occupation women,the control measures should be enhanced.