帕罗西汀在治疗抑郁症中的临床应用

Clinical application of Paroxetin in treatment of depression

目的:探讨帕罗西汀在治疗抑郁症中的临床应用疗效及安全性。方法:选取228例抑郁症患者,随机均分为帕罗西汀组和度洛西汀组两组,均口服给药,治疗6周,以汉密尔顿抑郁量表(HAMD)和汉密顿焦虑量表(HAMA)作为疗效评价指标。结果:帕罗西汀组患者有效率为86.3%,度洛西汀组患者为86.8%,两组患者比较差异无显著性(P>0.05);帕罗西汀组患者不良反应发生率低于度洛西汀组,差异有统计学意义(P<0.05)。结论:应用帕罗西汀治疗抑郁症临床疗效显著,不良反应率低。

Objective：To investigate the clinical efficacy and safety of Paroxetine in treatment of depression. Methods：228 ca-ses with depression were randomly divided into duloxetine group and Paroxetine group and were orally treated for 6 weeks. The efifcacy was evaluated with Hamilton depression scale （HAMD） and Hamilton anxiety scale （HAMA）. Results： The effective rate of Paroxe-tine group was 86. 3% , while that of duloxetine group was 86. 8% , and the difference was not significant （P〉0. 05）. The incidence rate of adverse reactions of Paroxetine group was lower that that of duloxetine group, and the difference was statistically significant （P〈0. 05）. Conclusions： Paroxetine in the treatment of depression has significant effects and less adverse reactions.