中药灌肠联合氟西汀治疗腹泻型肠易激综合征的临床分析

Clinical analysis of traditional Chinese medicine enema combined with Fluoxetine in treatment of diarrhea-predominated irritable bowel syndrome

目的:通过中药灌肠联合氟西汀与单用氟西汀治疗肠易激综合征的对照研究,探讨中药联合氟西汀治疗肠易激综合征的疗效。方法:将68例符合罗马Ⅲ诊断标准的肠易激综合征患者随机分为治疗组和对照组各34例,治疗组患者给予中药灌肠联合氟西汀治疗4周,对照组患者给予氟西汀治疗4周,评定临床疗效及不良反应。结果:治疗4周后两组患者临床症状均能明显改善,治疗组患者总有效率为92.62%,对照组患者总有效率为68.56%,治疗组总有效率明显高于对照组,两组患者治疗的有效率差异有显著性(P<0.01)。结论:中药灌肠联合氟西汀与单用氟西汀治疗肠易激综合征疗效好,不良反应小。

Objective：To control study the efficacy of traditional Chinese medicine（TCM） enema combined with fluoxetine and single Fluoxetine in treatment of irritable bowel syndrome, and discuss the efficacy of the former. Methods：According to the criteria of Rome III for irritable bowel syndrome, 68 patients were randomly divided into two groups. The treatment group patients were treated by TCM enema combined with fluoxetine for 4 weeks and the control group patients were treated by fluoxetine for 4 weeks. The clinical ef-ficacy and side effects in the study were evaluated. Results： The clinical symptoms of the two group were significantly improved after 4 weeks＇ treatment. The total effective rate of treatment group （92. 62% ） was significantly higher than that of control group （68. 56% ）, and there was a significant difference between the two groups （P〈0. 01）. Conclusions： The TCM enema combined with fluoxetine in the treatment of irritable bowel syndrome has good curative effects and less side effects.