摘要
目的:在经典的formalin诱导的条件位置回避模型的基础上,结合本实验室条件探索一种新的痛情绪测量。方法:完全弗氏佐剂(CFA)诱导的条件性位置回避。方法:雄性SD大鼠左侧足底皮下注射完全弗氏佐剂,建立条件性位置回避(CPA)模型。结果:SD大鼠足底皮下注射CFA会引起持续的炎性疼痛,可以产生稳定的条件性位置回避。足底注射生理盐水(NS)组和空白对照(naive)组不能产生条件性位置回避。结论:CFA诱导的CPA模型可以作为痛情绪量化的一种方法。
To explore a new method for measuring pain mood:Complete Freund’s adjuvant(CFA)-induced CPA model to measure affective dimension of pain,based on the classical formalin of conditioned place avoidance (F-CPA)model and our laboratory conditions.Method:The male Sprague-Dawley(SD)rats’left hind paw were given hypodermic injection the CFA,successfully established CFA induced CPA model in rat.Result:Compared with the injection of normal saline(NS)group and blank control group,intra-plantar injection of CFA induced persistence inflammatory pain and stabile CPA.Conclusion:CFA-induced CPA model in rat can be a method of reflecting pain-related negative emotion.
出处
《中国医学创新》
CAS
2014年第18期45-48,共4页
Medical Innovation of China
基金
国家自然科学基金资助项目(81371254)
关键词
完全弗氏佐剂
条件性位置回避
持续性炎性痛
痛情绪
大鼠
Complete Freund’s adjuvant
Conditioned place avoidance
Persistence inflammatory pain
Affective dimension of pain
Rat