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痛情绪反应量化方法的探索 被引量：10

Exploration of Pain Emotional Response Quantization Method
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摘要 目的:在经典的formalin诱导的条件位置回避模型的基础上,结合本实验室条件探索一种新的痛情绪测量。方法:完全弗氏佐剂(CFA)诱导的条件性位置回避。方法:雄性SD大鼠左侧足底皮下注射完全弗氏佐剂,建立条件性位置回避(CPA)模型。结果:SD大鼠足底皮下注射CFA会引起持续的炎性疼痛,可以产生稳定的条件性位置回避。足底注射生理盐水(NS)组和空白对照(naive)组不能产生条件性位置回避。结论:CFA诱导的CPA模型可以作为痛情绪量化的一种方法。 To explore a new method for measuring pain mood：Complete Freund’s adjuvant（CFA）-induced CPA model to measure affective dimension of pain,based on the classical formalin of conditioned place avoidance （F-CPA）model and our laboratory conditions.Method：The male Sprague-Dawley（SD）rats’left hind paw were given hypodermic injection the CFA,successfully established CFA induced CPA model in rat.Result：Compared with the injection of normal saline（NS）group and blank control group,intra-plantar injection of CFA induced persistence inflammatory pain and stabile CPA.Conclusion：CFA-induced CPA model in rat can be a method of reflecting pain-related negative emotion.
作者 张肖怡 兰坤 冯晓璞 宋瑞瑞 张策 张宇
机构地区 山西医科大学生理学系 山西医科大学医学影像系 山西医科大学第一临床医学院
出处 《中国医学创新》 CAS 2014年第18期45-48,共4页 Medical Innovation of China
基金 国家自然科学基金资助项目(81371254)
关键词 完全弗氏佐剂 条件性位置回避 持续性炎性痛 痛情绪 大鼠 Complete Freund’s adjuvant Conditioned place avoidance Persistence inflammatory pain Affective dimension of pain Rat
分类号 R96 [医药卫生—药理学]
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参考文献17

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二级参考文献23

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共引文献15

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引证文献10

二级引证文献23

中国医学创新
2014年 第18期

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