慢性阻塞性肺病患者血浆C反应蛋白及D-二聚体的变化研究

Study on Change of Plasma C-reactive Protein and D-dimer in Patients with Chronic Obstructive Pulmonary Disease

目的:对慢性阻塞性肺病患者血浆C反应蛋白及D-二聚体的变化进行研究。方法:选取2012年1月-2013年12月本院收治的89例慢性阻塞性肺疾病患者,其中稳定期患者43例(COPD组),急性加重期患者46例(AECOPD组),选取同期44例健康体检者作为对照组。对所有患者均采集静脉血进行C反应蛋白及D-二聚体的检测,观察比较三组的观察指标含量及阳性率。结果:与健康对照组比较,COPD组、AECOPD组的血浆C反应蛋白及D-二聚体含量均明显增高,且AECOPD组更为显著,而治疗后明显低于治疗前,差异均有统计学意义(P<0.05)。COPD组、AECOPD组的血浆C反应蛋白及D-二聚体的检测阳性率均明显高于健康对照组,AECOPD组明显高于COPD组,差异均有统计学意义(P<0.05)。结论:C反应蛋白及D-二聚体联合检测对COPD患者的早期诊断、治疗、病情评估及预后观察具有重要的临床价值。

To study the change of plasma C-reactive protein and D-dimer in patients with chronic obstructive pulmonary disease.Method：89 patients with chronic obstructive pulmonary disease from January 2012 to December 2013 in our hospital were selected,including 43 stable patients（the COPD group）,46 patients with acute exacerbation（the AECOPD group）.44 healthy people during the same period were selected as the control group. All patients were conducted C-reactive protein and D-dimer blood collection and testing,content and positive rate of indicators in the three groups were observed and compared.Result：Compared with the healthy control group,the plasma C-reactive protein and D-dimer levels in COPD group and AECOPD group were significantly higher,AECOPD group was more significant,but after treatment,it was significantly lower than before treatment,the differences were statistically significant（P〈0.05）.The plasma C-reactive protein and D-dimer testing positive rate in COPD group and AECOPD group were significantly higher than the healthy control group,AECOPD group was significantly higher than the COPD group,the differences were statistically significant（P〈0.05）.Conclusion：C-reactive protein and D-dimer have important clinical value in the early diagnosis,treatment,evaluation and prognosis of patients with COPD.