急性冠脉综合征患者血浆中NT-proBNP和hs-CRP联合检测的应用价值

Combined detection of plasma levels of N-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein for patients with acute coronary syndrome:an investigation of its clinical value

目的检测急性冠脉综合征(ACS)患者血浆中氨基末端钠尿肽前体(NT-proBNP)和超敏CRP(hs-CRP)含量水平,以探讨其在ACS诊断及预后评估中的应用价值。方法将126例ACS患者作为观察组,58例健康体检者作为对照组;用放射免疫分析法和vitros ECi免疫发光法同时检测2组样本血浆中的hs-CRP和NT-proBNP含量水平,并采用t检验比较2组的x珋±s差异有无显著性,对NT-proBNP与hs-CRP水平关系运用Pearson相关性分析。结果ACS患者组血浆中的NT-proBNP和hs-CRP含量水平均显著高于对照组(P<0.01),对NT-proBNP与hs-CRP浓度水平关系运用Pearson相关性分析,结果表明二者呈显著正相关(P<0.05)。结论联合检测血浆中的NT-proBNP和hs-CRP含量水平,对ACS的诊断和预后评估具有较重要的价值。

Objective To investigate the levels of N-Terminal proB-Type natriuretic peptide （ NT-proBNP） and high-sen-sitivity C-reactive protein （hs-CRP） in plasma of patients with acute coronary syndrome （ACS）,and to explore the clinical meanings.Methods 126 ACS patients were set as an observation group ,and 58 healthy adults as a control group .Radiation immunity analysis method and vitros ECi immune luminescence detection were applied simultaneously to detect the hs -CRP and the NT-proBNP levels in plasma of two sets of samples;x±s of the two groups were calculated respectively by using t test to compare differences .Pearson correlation analysis was conducted to analyze the relationship between the NT -proBNP and hs-CRP levels.Results In comparison with the normal controls ,the levels of NT-proBNP and hs-CRP were higher in ACS pa-tients.The difference was significant（P〈0.01）.The level of NT-proBNP was positively correlated with that of hs-CRP（P〈0.05）.Conclusion Combined detection of plasma levels of NT-proBNP and hs-CRP is of clinical value for the diagnosis and prognosis of ACS .