老年2型糖尿病患者认知障碍情况调查及影响因素分析

The Investigation of the Situation and Risk Factors of Mild Cognitive Impairment in Older Patients with Type 2 Diabetes Mellitus

目的分析老年2型糖尿病患者认知障碍情况及其影响因素。方法选取内江市中医院2012年2月至2013年3月收治的130例老年糖尿病患者作为研究对象,采用蒙特利尔认知评估(MoCA)量表进行调查,根据有无认知障碍分为认知障碍组与对照组,对两组患者的相关指标进行对比分析。结果 130例患者中,存在轻度认知障碍的患者有51例,占39.23%;两组患者在C肽水平、糖尿病病程、高血压病史、高血压病程方面比较差异有统计学意义(P<0.05)。两组颈动脉左侧、右侧、最大、最小内膜中层厚度(IMT)和最小阻力指数(RI)比较差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,IMT、RI、高血压病史、糖尿病病程、高血压病程以及C肽水平是老年2型糖尿病患者发生认知障碍的主要危险因素(P<0.05)。结论糖尿病患者IMT、RI、高血压病史、糖尿病病程、高血压病程以及C肽水平可能是老年2型糖尿病患者出现认知障碍的危险因素。

Objective To study the situation of cognitive impairment in elderly patients with type 2 diabetes and its influencers.Methods A total of 130 cases of elderly diabetic patients in Neijiang Hospital of Traditional Chinese Medicine from Feb.2012 to Mar.2013 were included as the research objects,Montreal cognitive assessment（MoCA） questionnaire was used for investigation,and the objects were divided into cognitive impairment group and control group according to the presence or absence of cognitive impairment,the indexes of the two groups were compared.Results Among the 130 patients,there were 51 cases of mildcognitive impairment,accounting for 39.23 % ;the two groups had statistically significant difference in the C peptide level,duration of diabetes,hypertension,minimum carotid artery resistance index,maximum carotid intima-media thickness（P 〈 0.05）.Multivariate Logistic regression analysis showed,IMT,RI,history of hypertension,diabetes mellitus,hypertension duration and C peptide level were the main risk factors for cognitive impairment in elderly patients with type 2 diabetes（P 〈 0.05）.Conclusion IMT,RI,hypertension history,duration of diabetes and hypertension,and peptide C levels may be the risk factors for cognitive impairment in elderly diabetic patients.