米非司酮配伍米索前列醇在病理妊娠中的应用

Application of Mifepristone Combined with Misoprostol in Pathological Pregnancy

目的探讨米非司酮配伍米索前列醇在病理妊娠中的应用。方法选取2010年1月至2012年12月武安市新兴际华医院收治的病理妊娠患者100例,所有患者均自愿要求引产。将所有患者按照随机数字表法分为联合治疗组和传统治疗组,每组50例,联合治疗组口服米非司酮配伍米索前列醇引产,传统治疗组采用传统口服依沙吖啶100 mg引产,对两组的引产效果进行比较。结果联合治疗组的引产成功率显著大于传统治疗组(98.0%vs 84.0%),引产总产程[(4.6±2.1)h vs(8.4±4.2)h]、引产出血量[(52.7±23.6)mL vs(97.2±34.5)mL]、清宫刮出物量[(32.8±17.4)mL vs(68.7±34.8)mL]以及胎盘滞留数(4 vs 15)均显著小于传统治疗组(P<0.05),同时两组患者在治疗过程中均未出现羊水栓塞和子宫破裂等并发症,少数出现不良反应的患者反应均轻微,且为一过性,无需特别处理。结论米非司酮配伍米索前列醇在各种病理妊娠中的应用疗效确切,具有简单易行、用药方便、成功率高、安全有效、出血量少、不良反应少等特点,值得临床推广。

Objective To investigate the application of mifepristone and misoprostol in pathological pregnancy.Methods A total of 100 patients with pathological pregnancy admitted to Wu＇an City Xinxing Jihua Hospital during Jan.2010 to December 2012 were selected,all patients voluntarily requested abortion,and were randomly divided into combined treatment group and traditional treatment group in accordance with the random number table method,50 cases in each group：the combination therapy group received mifepristone and misoprostol（oral） for induction,the conventional treatment group received traditional ethacridine （oral,100 mg） for induction,the effect of the induced abortion of both groups were compared.Results The induction success rate of combined treatment group was significantly higher than the conventional treatment group（98.0% vs 84.0%）,total production process[（4.6 ± 2.1） h vs （8.4 ± 4.2） h],bleeding during induction[（52.7 ±23.6） mL vs （97.2 ±34.5） mL],curettage amount[（32.8 ± 17.4） mL vs （68.7 ± 34.8） mL] and placenta reserve number（4 vs 15） were all significantly less than the conventional therapy group（P 〈 0.05）,while no complications of amniotic fluid embolism and uterine rupture occurred in either group during treatment,a small number of patients had mild and trasient adverse reactions needing no special treatment.Conclusion The efficacy of mifepristone combined with misoprostol has affirmative effect in pathological pregnancy,with the features of simple,convenient medication,high success rate,safe and effective,less bleeding,and adverse reactions etc.,thus is worthy of promotion in clinical.