骨质疏松症与老年钙化性瓣膜病相关性认识

Correlation between Osteoporosis and Senile Calcified Valvular Disease

随着人类寿命的延长,老年钙化性瓣膜病(SCVD)在老年人群中发生率日益增加,该病是随年龄增长,瓣膜出现老化、退行性改变、钙盐沉积等一系列变化,导致瓣膜功能障碍,严重时可导致血流动力学异常,是老年人晕厥、猝死的重要原因。骨质疏松症(OP)是一种以骨量减少为特征的全身性骨骼疾病。SCVD患者多伴有骨量丢失,许多危险因素和机制同时导致骨量丢失和瓣膜钙化,包括高龄、高血脂、糖尿病、吸烟、活性维生素D3生成减少、骨密度减低、性激素缺乏等,两者可能存在一定的相关性,该文就总结当前研究进展,评价OP与SCVD的潜在相关性。

As the extension of human life, senile calcified valvular disease （SCVD） ineidenee is increasing in the elderly. With the age growing, the valves experience a series of changes ： aging and degenerative changes, calcium salt deposition,then lead to valve dysfunction, and may cause abnormal hemodynamie disorder, which is an important cause of syncope and sudden death in the elderly. Osteoporosis （OP） is a systemic skeletal disease, characterized by bone loss. SCVD patients frequently suffer from bone loss, and various common risk factors and mechanisms have been suggested to cause both bone loss and vascular calcification, including aging, hyperlipidemia, diabetes, smoking, decreased aetive vitamin D3 generation,low bone mineral density,lack of sex hormones and so on. There might be a certain correlation between the two, and here is to make a review of the current data and evaluate potential relevance of OP and SCVD.