摘要
目的 探索孕妇甲状腺自身抗体与早产风险的关系.方法 检索并纳入相关前瞻性队列研究,利用荟萃分析计算甲状腺自身抗体阳性孕妇早产风险的相对危险度（RR）值及其95％可信区间（CI）.结果 纳入9个研究,荟萃分析显示甲状腺自身抗体阳性孕妇发生早产的RR值为1.63（95％CI 1.16～2.27,P=0.003）.亚组分析显示,在对照组甲状腺功能正常的亚组和未排除甲状腺功能异常者的亚组中,甲状腺自身抗体均增加早产风险.结论 甲状腺自身抗体增加早产风险.
Objective To evaluate the relationship between thyroid autoantibody and preterm labor risk in pregnant women. Methods Relevant studies were searched and included into this meta-analysis. Pooled relative risk（RR） with its corresponding 95% confidence intervals（95% CI） was calculated using meta- analysis. Results 9 cohort studies were included into our meta-analysis, and the pooled RR of preterm labor for pregnant women with thyroid autoantibedy was 1.63 （95% CI 1. 16-2.27 ,P =0. 003 ）. Subgroup analysis yielded thyroid autoantibody increased preterm labor risk in both the subgroup analysis of controls restricted to euthyroid and the subgroup analysis of controls containing thyroid dysfunction. Conclusion Thyroid autoantibody increases preterm labor risk.
出处
《医学综述》
2014年第11期2050-2051,2055,共3页
Medical Recapitulate
关键词
甲状腺自身抗体
早产
荟萃分析
Thyroid autoantibody
Preterm labor
Meta-analysis
