Ets-1在宫颈腺癌组织中的表达及预后研究

The Expression of Ets-1 in Cervical Adenocarcinoma and Its Prognosis Study

目的探讨Ets-1在宫颈腺癌组织中的表达及其与预后的关系。方法收集2006年3月至2008年2月在尚义县医院就诊的80例宫颈腺癌患者临床资料,采用免疫组织化学(EnVisionTM)法分别检测宫颈腺癌组织及癌旁组织中Ets-1的表达情况。结果 Ets-1在宫颈腺癌组织、癌旁组织中的阳性表达率分别为52.50%和7.50%,两者比较差异有统计学意义(χ2=23.04,P<0.01);Ets-1的表达与肿瘤大小、淋巴结转移、远处脏器转移、TNM分期有关(χ2=6.57,6.13,6.67,3.87,P<0.05),但与年龄、组织学类型无关(χ2=1.23,0.23,P>0.05);生存分析显示,Ets-1蛋白阴性患者的生存率显著高于阳性患者(χ2=4.18,P<0.05)。结论 Ets-1在宫颈腺癌组织中过表达,其表达水平预示着患者的生存差。

Objective To investigate the expression of Ets-I in cervical adenocarcinoma and its relationship with the prognnsis. Methods Clinical data of 80 cases from Shangyi County Hospital during Mar. 2006 and Feb. 2008 were collected. The expression of Ets-I was respectively detected by immunohistochemistry （ F.nVision TM） in cervical adenoearcinoma and paracancerous tissue. Results The positive expression rate of Ets-I protein in cervical adenocarcinoma and paracaneerous tissue was respectively 52.50% and 7.50%, which was statistically significantly different（ x^2 = 23.04, P 〈 0. 05 ）. The positive expression of Ets-I was related to tumor size,lymph node metastasis, distant organ metastasis, and TNM staging（ x^2 = 6.57,6. 13, 6.67,3.87, P 〈 0. 05 ） , but not age and histological type （ x^2= 1.23,0.23, P 〉 0.05 ）. Survival analysis showed that the survival rate of negative Ets-I was obviously higher than positive Ets-1 （x^2= 4.18, P 〈 0.05 ）. Conclusion Ets-1 is overexpressed in cervical adenocarcinoma, and the expression level implies poor survival of the patients.