龙血竭酚类成分研究

Phenolic constituents from Draconis Resina

目的研究龙血竭Draconis Resina的酚类化学成分。方法利用硅胶、Sephadex LH-20柱色谱及半制备液相等色谱方法分离纯化,结合其理化性质及MS、NMR等光谱数据鉴定化合物的结构。结果从龙血竭醋酸乙酯提取部位分离得到14个化合物,分别鉴定为4′-羟基-1′,4″-二甲氧基查尔烷（1）、7-羟基-5,4′-二甲氧基-2-苯基苯并呋喃（2）、紫檀茋（3）、3,4′-二羟基-5-甲氧基二苯乙烯（4）、5,7,4′-三羟基二氢黄酮（5）、瑞士松素（6）、7-羟基二氢黄酮（7）、甘草素（8）、对羟基苯甲酸甲酯（9）、4-羟基-3-甲氧基苯甲酸甲酯（10）、4-羟基-3-甲氧基苯甲酸乙酯（11）、2,4-二羟基苯乙酮（12）、3,4-二羟基烯丙基苯（13）和β-谷甾醇（14）。结论化合物1为新天然产物,化合物2为首次从百合科植物中分离得到,化合物5、9-12为首次从龙血树属植物中分离得到,化合物6-7为首次从剑叶龙血树中分离得到。

Objective To study the phenolic constituents of Draconis Resina.Methods The compounds were isolated and purified by silica gel and sephadex LH-20 column chromatography,and their structures were identified by physiochemical properties and MS and NMR spectroscopic data.Results Fourteen compounds were isolated from the ethyl acetate extract of Draconis Resina and identified as 4′-hydroxy-1′,4″-dimethoxychalcane（1）,7-hydroxy-5,4′-dimethoxy-2-arylbenzofuran（2）,pterostilbene（3）,3,4′-dihydroxy-5-methoxystilbene（4）,5,7,4′-trihydroxyflavanone（5）,pinocembrin（6）,7-hydroxyflavanone（7）,liquiritigenin（8）,methyl 4-hydroxybenzoate（9）,methyl 4-hydroxy-3-methoxybenzoate（10）,ethyl 4-hydroxy-3-methoxybenzoate（11）,2,4-dihydroxy acetophenone（12）,3,4-dihydroxyallybenzene（13）,and β-sitosterol（14）.Conclusion Compound 1 is a new natural product.Compound 2 is firstly obtained from the plants of Liliaceae.Compounds 5 and 9—12 are firstly isolated from the plants of Dracaena Vand.ex L.,and compounds 6 and 7 are isolated from Dracaena cochinchinensis for the first time.