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吡哆醛双缩二氨基硫脲及其Cu(Ⅱ)配合物的合成与生物活性探究 被引量：4

Synthesis and biological activity of pyridoxal thiocarbohydrazone and its copper(Ⅱ) complexes
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摘要 合成了吡哆醛双缩二氨基硫脲(H2L)及其Cu(Ⅱ)配合物(CuL),通过H1NMR、IR、UV和HRMS进行了表征。用分光光度法确定了配合物的组成及稳定常数。初步生物活性试验表明:配体(H2L)及其Cu(Ⅱ)配合物(CuL)对大肠杆菌和金黄色葡萄球菌均具有较好的抑制作用。 The syntheses of pyridoxal thiocarbohydrazone Schiff base（ H2 L） and its copper（ Ⅱ） complexes（ CuL） were reported. Their structures were characterized by H1 NMR,IR,UV and HRMS. Moreover,the component and the stability constant of the coordination compounds（ CuL） were investigated though UV spectrophotometry. Biological activity tests showed that both of H2 L and CuL exhibi-ted some antibacterial activities to Escherichia coli and Staphylococcus aurous.
作者 边俊鹏 王剑锋 尹静梅 刘宝全 边萌萌 武天娇 权春善 范圣第
机构地区 大连大学 大连民族学院生命科学学院、国家民委-教育部生物化工重点实验室
出处 《化学研究与应用》 CAS CSCD 北大核心 2014年第6期843-847,共5页 Chemical Research and Application
基金 国家自然科学基金项目(21272031)资助 大连民族学院自主科研基金重点项目(DC120101183)资助
关键词 吡哆醛 二氨基硫脲 配合物 抑菌活性 pyridoxal thiocarbohydrazone coordination compound antibacterial activity
分类号 O625.45 [理学—有机化学]
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参考文献18

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化学研究与应用
2014年 第6期

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