摘要
针对复杂的大规模微流控芯片,提出了一种新的通用微流控系统行为模拟方法,计算芯片中由压力驱动的,线性和非线性的,静态和动态的溶液、溶质传输。对芯片中溶液/溶质传输的对流-扩散方程进行了分析,定义新的节点变量,抽象出系统集总模型,通过空间离散化处理,考虑了管壁柔性对模型参数的影响,建立毛细管传输的数值模型。新方法可以避免复杂解析解的求解,计算时间短。利用Verilog-AMS语言实现了模型建立和求解,开发了具体应用程序,对自制微流控开关梯度发生器及脉冲编码调制器进行模拟和分析,通过对比仿真和实验结果,验证了方法的有效性。
A novel simulation method for obtaining approximate solution of linear and nonlinear, static and time-dependent solute and solvent transport in large chips was developed. The method was based on a one-dimensional space discretization of the convection-diffusion equation which tracks solvent and solute transport using four dual-branch nodal quantities. The lumped model was implemented in a hardware language such as Verilog-AMS and detailed codes were presented. Furthermore, comparison of the static and transient behavior of a microfluidic switching gradient generator and a PCM signal generator indicates that the experimental results are in good agreement with the model simulation.
出处
《高校化学工程学报》
EI
CAS
CSCD
北大核心
2014年第3期641-647,共7页
Journal of Chemical Engineering of Chinese Universities
基金
国家自然科学基金(41275037)
安徽省自然科学基金(1308085QF124)
关键词
微流控系统
溶液
溶质传输
集总模型
有限差分
Verilog-AMS
microfluidics
solvent/solute transport
lumped model
finite difference
Verilog-AMS
