急性脑梗死病人血浆内皮素的变化及尼莫地平对其的影响

Plasma endothelin in acute cerebral infarction and its change after nimodipine treatment

目的 :了解急性脑梗死病人血浆内皮素(ET)的变化以及尼莫地平对它的影响。方法 :66例急性脑梗死 (ACI)病人根据入院时的血压情况随机分为 2组 :高血压脑梗死组 35例 [男性 2 0例 ,女性 15例 ,年龄 ( 65±s11)a]和单纯脑梗死组 31例[男性 17例 ,女性 14例 ,年龄 ( 62± 10 )a]。采用放射免疫法测定ET浓度 ,并与 2 7例健康对照者比较 ,其中 4 2例ACI病人 ( 2组分别为 2 5例和 17例 )接受尼莫地平 4mg ,iv ,gtt ,qd ,2wk后复测ET。结果 :2组脑梗死病人血浆ET浓度分别为 ( 144±4 2 )ng·L- 1和 ( 72± 35)ng·L- 1。尼莫地平治疗后 ,分别为 ( 94± 55)ng·L- 1和 ( 60± 37)ng·L- 1,但仍高于对照组 (P <0 .0 1)。结论 :ET与ACI有着密切联系 ;尼莫地平静滴在明显改善神经症状的同时可明显降低ET。

AIM: To explore the role of plasma endothelin (ET) in patients with acute cerebral infarction (ACI) and its change after nimodipine treatment.METHODS:Sixty six patients with ACI were randomly divided into 2 groups according to blood pressure:hypertension ACI group 35 patients[M 20,F 15;age (65± s 11) a] and pure ACI group 31 patients[M 17,F 14; age (62±10) a].Plasma ET was measured by radioimmunoassay and compared with 27 healthy individuals.Among them,42 patients(hypertension ACI group 25 patients,pure ACI group 17 patients) with ACI were given nimodipine 4 mg, iv,gtt, qd, for 2 wk and measured ET again. RESULTS:Plasma ET in 2 groups were (144±42) ng·L -1 and (72±35) ng·L -1 respectively, and that were (94±55) ng·L -1 and (60±37) ng·L -1 respectively after treatment with nimodipine, but was still higher than that in healthy individuals ( P < 0.01 ). CONCLUSION: The level of plasma ET was associated with blood pressure and the severity of disease. ET is closely related with ACI. Nimodipine reduces the plasma ET while nerve function default degree is effectively improved.