2-呋喃甲醛缩苯甲酰腙铜、钴配合物的合成与抑菌活性研究

Synthesis and Antibacterial Activities of Cu(Ⅱ) and Co(Ⅱ) Complexes of 2-Furaldehyde Benzoylhydrazone

通过2-呋喃甲醛与苯甲酰肼缩合得到酰腙配体2-呋喃甲醛缩苯甲酰腙(L),将L与CuCl2·2H2O、CoCl2·6H2O分别在乙醇-丙酮的混合溶剂中反应,采用溶剂挥发法获得两个不同构型的配合物CuL2(1)和CoCl(Py)L2(2)单晶。采用元素分析、红外光谱、X-射线单晶衍射等手段对配合物1和2进行结构表征,表明配合物1和2均属于单斜晶系,空间群分别为C2/c和P2(1)/c。配合物1属于平面四方构型,晶胞参数a=0.5782(5),b=2.392(2),c=1.7361(14)nm,β=117.328(12)°,Z=4;配合物2属于四角双锥构型,晶胞参数a=2.1357(13),b=0.9533(5),c=1.3419(8)nm,β=99.181(12)°,Z=4。热重测试表明配合物1和2均有很好的热稳定性。用琼脂扩散法测定了配体和配合物对大肠杆菌、金黄色葡萄球菌、绿脓杆菌的抑制活性,结果显示配合物1对大肠杆菌有更好的抑制活性,配合物2对金色葡萄球菌有更强的抑制活性。

A novel acylhydrazone ligand which called 2 - furaldehyde benzoylhydrazone had been synthesized from 2 - furancarbaldehyde and benzoyl hydrazine. Two different configurations metal complexes of the ligand which named CuL2 （1） and CoCI（Py） L2 （2） were also synthesized in mixed solvent of ethanol and acetone with CuCl2 · 2H2O or CoCl2 · 6H2O. The single crystal of complex 1 and 2 were obtained through solvent evaporation method. Complex 1 and 2 were characterized by using EA, FT - IR X - ray and other means. Complex 1 and 2 crystallizes both in the monoclinic system. Complex 1 had square planar configuration in the space group C2/c with a =0.5782（5） ,b = 2.392 （ 2）, c = 1. 7361 （ 14 ） nm, parameters ,β = 117. 328 （12） °, Z = 4 ; Complex 2 had distorted octahedral configuration in the space group P2（ 1 ）/c with a =2. 1357（13） ,b =0. 9533（5） ,c = 1. 3419（8） nm parameters β = 99.181 （ 12 ） °, Z = 4. The thermal stability of two complexes was good. The ligand and its metal complexes had been screened for their antibacterial activities by agar diffusion method. The result showed that complex 1 had better antibacterial activity to Escherichia coli and complex 2 had better antibacterial activity to Staphylococcus aureus. CCDC ：CuL2 ,926192 ; CoCI（Py） L2 ,958493.