文拉法辛与呋喃唑酮治疗有害饮酒的比较

Venlafaxine vs furazolidone in treating harmful alcoholics

目的 :比较文拉法辛与呋喃唑酮对有害饮酒治疗的疗效、不良反应以及治疗过程中的心境变化。方法 :有害饮酒者共 68例均为男性 ,分为 2组。文拉法辛组 34例 ,年龄 37a±s 6a ,给文拉法辛 2 5～ 50mg ,po ,tid。呋喃唑酮组 34例 ,年龄 38a± 6a ,给呋喃唑酮 0 .1～ 0 .2 g ,po ,tid ,在服用呋喃唑酮期间 ,间断饮用白酒。结果 :文拉法辛组 ,3mo戒断总有效率 79% ,治疗过程中不良反应不明显 ,焦虑、抑郁分数较低。呋喃唑酮组戒断治疗总有效率65% ,与文拉法辛组相比差异有显著意义 (P <0 .0 5)。治疗过程中出现血压变化、心肌缺血等药物不良反应较重 ,治疗后的焦虑、抑郁分数较高。结论 :文拉法辛治疗有害饮酒不良反应少于呋喃唑酮 。

AIM: To compare the effects, adverse reactions and emotion change of venlafaxine vs furazolidone for harmful alcoholics. METHODS: Sixty eight patients with harmful alcoholics were divided into two groups. Thirty four patients (M34; age 37 a± s 6 a) were treated with venlafaxine, 25-50 mg, po, tid, for 8 wk. The other thirty four patients (M34;age 38 a±6 a) with furzolidone, 0.1-0.2 g, po, tid, for 8 wk, with drinking alcohol at regular intervals during treating with furazolidone. RESULTS: The total effective rate was 79% in venlafaxine group at 3 mo. There were no obvious adverse reactions, the anxiety disorder and depressive disorder during treating with venlafaxine. And the total effective rate was 65% in furazolidone group ( P <0.05). There were obvious adverse reactions such as hypotension, myocardial ischemia, anxiety disorder and depressive disorder after treating with furazolidone. CONCLUSION: Adverse reaction of venlafaxine on harmful alcoholics is smaller than furazolidone and the effect of venlafaxine on alcoholics is better than furazolidone.