卡尼汀治疗急性脑梗死

Carnitine in treatment of acute cerebral infarction

目的 :观察卡尼汀治疗急性脑梗死的疗效及不良反应。方法 :135例经CT或MRI证实的急性脑梗死病人随机分为 2组。在常规治疗基础上卡尼汀组 68例 (男性 37例 ,女性 31例 ;年龄 60a±s17a) ,用卡尼汀 2～ 3g溶于氯化钠注射液 2 0 0mL ,静脉滴注 ,qd× 2 8d。对照组 67例 (男性 39例 ,女性 2 8例 ;年龄 63a± 17a) ,用右旋糖酐 4 0葡萄糖注射液 50 0mL加复方丹参注射液 2 0mL ,静脉滴注 ,qd× 2 8d。结果 :卡尼汀组总有效率为 80 % ,对照组总有效率为 55% ,P <0 .0 5。治疗期间未发现不良反应。结论 :卡尼汀治疗急性脑梗死是安全。

AIM: To study the efficacy and adverse reactions of carnitine on patients with acute cerebral infarction. METHODS: One hundred and thirty five patients with acute cerebral infarction diagnosed by CT or MRI were randomly divided into 2 groups, on the basis of conventional therapy. Sixty eight patients in carnitine group (M37,F31; age 60 a± s 17 a) received carnitine 2-3g, iv, drip, qd for 28 d. The other 67 patients of control group (M39, F28; age 63 a±17 a) received compound salvia miltirrhiza 20 mL in dextran 40 glucose injection 500 mL, iv, drip, qd for 28 d. RESULTS: The total effective rates of carnitine group and control group for acute cerebral infarction were 80% and 55%, respectively ( P <0.05). No adverse reactions were found. CONCLUSION: Carnitine is safe and effective in the treatment of acute cerebral infarction.