国产与进口维库溴铵对肌松作用的比较

Domestic vs imported vecuronium bromide on effects of muscular relaxation

目的 :比较国产与进口维库溴铵的肌松效应 ,并观察其对心血管系统的影响。方法 :30例病人分成国产组与进口组。用 4个成串刺激 (train of fourstimulation ,TOF)测定各组肌松起效时间、10 %T1恢复时间、临床有效期、75%T1恢复时间和恢复指数。并在各组麻醉诱导前 ,诱导后插管前 ,插管后即刻 ,插管后 1,2 ,5min分别记录心率、动脉收缩压、舒张压。结果 :2组病人肌松起效时间、10 %T1恢复时间、临床有效期、75%T1恢复时间和恢复指数比较差异均无显著意义 (P >0 .0 5) ,各时点心率、动脉收缩压、舒张压比较差异亦无显著意义 (P >0 .0 5)。结论

AIM: To compare domestic and imported vecuronium bromide on the effects of muscular relaxation and cardiovascular system. METHODS: Thirty patients undergoing elective surgery were divided into domestic one group and exotic one group. The onset time, T 1 recovery to 10% of control, clinical duration, T 1 recovery to 75% of control and recovery index of each group were measured by train of four stimulation and recorded. The changes of arterial pressure and heart rate of each group were recorded before induction, before intubation, intubation, and 1,2,5 min after intubation. RESULTS: The changes of arterial pressure and heart rate were not obvious diffecance between two groups. The effect of muscular relaxation did not differ after administration either. CONCLUSION: The significant different changes between domestic and imported vecuronium bromide are not noticed. Both on the effects of muscular relaxation and cardiovascular system are similar.