药物性肝损伤诊断进展

Progress in the diagnosis of drug-induced liver injury

药物性肝损伤(DILI)是指在使用某一种或者几种药物后,由于药物本身或其代谢产物而引起的不同程度的肝损害。近年来,DILI的报道越来越多,但DILI症状发生率低,且缺乏特异性,易误诊。国内外DILI的诊断标准多样,对比各种诊断标准的优缺点,寻找最佳的诊断策略,对DILI的早期治疗和预后意义重大。

Drug-induced liver injury （DILI） refers to varying degrees of liver damage which caused by the drug itself or its metabolites. In recent years, there has been an increasing number of reports about DILI. However, it is often misdiagnosed for the low incidence of DILI symptoms and lack of specificity. There are various diagnostic criteria of DILI in dif erent countries. So it is of great significance to compare the advantages and disadvantages of these criteria and to find the best diagnostic strategy for early treatment and prognosis of DILI.