摘要
在临床上,肝窦阻塞综合征比较少见,近年来发病率逐年升高。其主要临床表现为顽固性腹水、黄疸、肝肿大。主要病因是摄入含吡咯烷生物碱的中草药或植物。目前早期诊断困难,无特效治疗方法,主要为对症和支持治疗。本文主要介绍摄入含吡咯烷生物碱的中草药导致的肝窦阻塞综合征的发病机制、病理学和临床表现,以及诊断和治疗方面的进展。
Hepatic sinusoidal obstruction syndrome is rare clinically,but the incidence is recently increased. The clinical manifestations are mainly refractory ascites,jaundice and hepatomegaly.The main causes is the ingestion of pyrrolizidine alka-loids-containing herbs or plants. The early diagnosis is currently difficult. There is no specific therapy for patients with hepatic sinusoidal obstruction syndrome,except for symptomatic and supportive therapy. This review mainly discuss the mechanism,pathol-ogy,early diagnosis,and therapy of this entity.
出处
《实用肝脏病杂志》
CAS
2014年第4期445-448,共4页
Journal of Practical Hepatology
关键词
肝窦阻塞综合征
中草药
吡咯烷生物碱
Hepatic sinusoidal obstruction syndrome
Traditional Chinese medicine
Pyrrolizidine alkaloids