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IL-18与疾病相关性的研究进展 被引量：4

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摘要 白细胞介素（ＩＬ）－１８可以诱生干扰素（ＩＦＮ）－γ，加强Ｆａｓ配体介导的细胞毒效应，增强ＩＬ－２、粒巨噬细胞集落刺激因子的活性，促进肿瘤坏死因子、ＩＬ－１、细胞间黏附分子－１、ＩＬ－８的表达，诱生ＩＬ－４，与ＩＬ－１２有协同作用。基础实验证实，ＩＬ－１８有抗感染、抗肿瘤的作用，并参与某些自身免疫性疾病、变态反应性疾病的发生。本文就现阶段ＩＬ－１８相关疾病的实验及临床研究进行综述，并对其应用前景进行展望。
作者 文维群 钱毅 章廉
机构地区 第一军医大学附属南方医院传染科
出处 《国外医学（儿科学分册）》 2001年第2期102-104,F003,共4页 Foreign Medical Sciences（Section of Pediatrics)
关键词 白细胞介素-18 感染性疾病 自身免疫性疾病
分类号 R392.3 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Yoshimoto T, Tsutsui H, Tominaga K, et al. 1L- 18, although antiallergic when administered with IL-12, stimulates IL- 4 and histamine release by basophils[J]. Proc Natl Acad Sci USA,. 1999,96(24):13962- 13966.
  • 2Rothe H, Hausmann A, Casteels K, et al. IL - 18 inhibits diabetes development in nonbese diabetic mice by counterregulation of Th1-dependent destructive insulitis[J]. J Immunol, 1999, 163(3):1230 - 1236.
  • 3Hu HE, Li GL, Lin YK, et al. Kinetics of interferon- gamma secrection and its tegulatory factors in the early phase of acute graft - versus - host disease[J]. Immunology, 1999,98(3):397 - 385.
  • 4Wild JS, Sihounas A, Sur N, et al. IFN - gamma - inducing factor (IL - 18) increases allergic sensitization, serum IgE, Th2 cytokines,and airway eosinophilia in a mouse model of allergic asthma[J]. J Immunol, 2000,64(5):2701 - 2710.
  • 5Barreios AP, Schirmacher P, Laufenberg- Feldmann R, et al. The early immune response in the liver of BALB/C mice infected with S. Typhimurium[J]. Scand J hmmunol, 2000,51(5):472- 478.
  • 6Ohkusu K,Yoshimoto T,Takeda K, et al. Potentiality of interleukin 18 as a useful reagent for treatment and prevention of leishmania major infection[J]. Infect Immun, 2000,68(5):2449- 2456.
  • 7Xing Z, Zganiacz A, Wang J, et al. IL- 12- independent Th1type immune response to respiratory viral infection: requirement of IL- 18 for IFN- gamma release in the lung but not for the differentiation of viral - reactive Th1 - type lymphocytes[J]. J Immunnology, 2000,164(5):2575 - 2584.
  • 8Tasaki K, Yoshida Y, Maeda T, et al. Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin- 12 or interleukin - 18, which activate type 1 helper Tcells[J]. Cancer Gene Therapy, 2000,7(2):247- 254.
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同被引文献17

  • 1李桦.反复呼吸道感染患儿的免疫功能[J].实用儿科临床杂志,1995,10(2):81-83. 被引量：39
  • 2Dorigo-Zetsma JW, Verkooyen RP, van Helden HP, et al. Molecular detection of Mycoplasma pneumoniae in adults with community-acquired pneumonia requiring hospitalization [ J ]. J Clin Microbiol, 2001,39 (3) : 1184-1186.
  • 3Furuya D, Yagigashi A, Yajima T, et al. An immuno-polymerase chain reaction assay for human interleukin-18 [ J ]. J Immunol Metbods, 2000, 238(1-2) : 173-180.
  • 4Yoshimoto T, Tsutsui H, Tominaga K, et al. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histarnine release by basophils[J ]. Proc Natl Acad Sci USA, 1999, 96 (24) : 13962-13966.
  • 5Wild JS, Sihounas A, Sur N, et al. IFN-gamma-inducing factor (IL18) increases allergic sensitization, serum IgE, Th2 cytoklnes, and airway eosinophilia in a mouse model of allergic asthma[J ]. J Immunol, 2000, 64(5) :2701-2710.
  • 6Zhu Z, Homer RJ, Wang ZD, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production [ J ]. J Clin Invest, 1999, 103(6):779-788.
  • 7Mozzarella G, Bianco A, Catena E, et al. Th1/Th2 lymphocyte polarization in asthma[ J ]. Allergy, 2000, 55 (Suppl) : 6-9.
  • 8Yoshineto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H.IL-18, although antialleipie when administered with IL-12 stimulates IL-4 and histamine release by basophils [J]. Proe Natl Acad Sci USA, 1999, 96(24): 13962 - 13966.
  • 9Wild JS, Sihounas A, Sur N, Siddiqui MS, Kurimoto M. IFNgamma-inducing factor (IL-18) increases allergic sensitization,serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma [J]. J Immunol, 2000, 64(5): 2701-2710.
  • 10Yoshimoto T,Tsutsui H.Tominaga K,et al.IL-18,although antiallergic when administered with IL-12 stimulates IL-4 and histamine release by basophils[J].Proc Natl Acad Sci USA,1999,(24):13962-13966.

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国外医学（儿科学分册）
2001年 第2期

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