摘要
目的 :探讨 1型血管紧张素Ⅱ受体 (AT1R)基因多态性与 2型糖尿病肾病 (DN)的关系。方法 :应用PCR DdeⅠ酶切法检测 35例并发DN及 82例无DN的 2型糖尿病 (DM )患者AT1R基因型。结果 :并发DN组突变基因型频率明显高于无DN组 (FisherexactP <0 .0 5,OR =3.2 0 2 ) ,突变等位基因频率亦高 (FisherexactP <0 .0 5,OR =3.2 51) ;Logistic逐步回归分析DN发生危险因素病程、果糖胺、收缩压进入方程。结论 :AT1R基因多态性与 2型糖尿病肾病有相关性 ,携带突变等位基因的 2型糖尿病患者具有发生DN的易感性。
Objective:To explore the association between angiotensin Ⅱ type 1 receptor(AT1R) gene polymorphism and type 2 diabetic nephropathy(DN).Methods:AT1R gene genotypes were determined by PCR/Dde Ⅰ restriction enzyme digestion technique in 35 DN patients and 78 diabetics not complicated with DN.Results:Frequency of variant genotypes in DN group was highter than that of not DN group(Fisher exact P< 0.05 ,OR=3.202) and frequency of variant allele was higher also(Fisher exact P<0.05,OR=3.251).Logistic stepwise regression showed duration,fructosamine and systolic blood pressure were risk factors of DN.Conclusion:AT1R gene is relation to type 2 diabetic nephropathy.Type 2 diabetics carrying variant gene are susceptible to DN.
出处
《山东医科大学学报》
2001年第1期10-12,共3页
Acta Academiae Medicinae Shandong
基金
山东省科委科研基金!资助项目 (1999BB1CJA2 )
关键词
血管紧张素受体
基因多态性
非胰岛素依赖性糖尿病
糖尿病肾病
Receotors,angiotensin
Gene polymorphism
Diabetes mellitus,non insulin dependent
Diabetic nephropathies
