利奈唑胺治疗儿童重症革兰阳性菌感染的回顾性分析

Retrospective analysis the effect of linezolid on severe Gram-positive bacteria infection in children

目的：探讨利奈唑胺治疗儿童重症革兰阳性菌感染的临床效果。方法回顾性分析以经验用药治疗无效而根据痰培养及药敏试验结果换用利奈唑胺治疗的重症革兰阳性菌感染患儿的临床资料。结果24例重症革兰阳性菌感染患儿经静脉滴注利奈唑胺（10 mg/kg，q8 h），疗程10~14 d，均显效或好转。结论在经验用药治疗无效时，选择利奈唑胺单用或联合其他药物治疗儿童重症革兰阳性菌感染可取得满意的临床效果。

Objective To investigate the clinical effect of linezolid on severe Gram-positive bacteria infection in chil-dren. Methods The retrospective analysis was performed in the clinical cases of severe Gram-positive bacteria infection which were insensitive to drugs selected from experience but sensitive to linezolid according to sputum culture and sensitivity test. Results Twenty-four children with severe Gram-positive bacterial infections were treated with linezolid by intravenous infusion （10 mg/kg, q8h） for 10-14 days. All of them were markedly improved. Conclusions When drugs selected from experiences are ineffective, linezolid or in combination with other drugs is a good choice in the treatment of severe Gram-positive bacterial infections.