影响肝豆状核变性患者心理状况相关因素分析

ANALYSIS OF THE RELATED FACTORS AFFECTING MENTAL HEALTH OF PATIENTS WITH WILSON DISEASE

目的:探讨影响肝豆状核变性(WD)患者心理状况的相关因素。方法:记录82例住院WD患者的一般临床资料、头颅CT或MR结果,采用统一wilson病神经功能评分标准(UWDRS)、Nazer肝功能评分标准、艾森克个性问卷(EPQ)、社会支持评定量表(SSRS)以及症状自评量表(Scl-90)对其进行评估及测查。统计分析可能影响其心理状况的各项因素。结果:WD患者不良心理问题发生率为46.3%。与其心理状况相关的因素有性格神经质维度、神经功能损害程度、肝功能损害程度、社会支持度及颅脑影像病变范围。多因素Logistic回归分析示神经功能损害(OR=8.708)、头颅影像病变范围(OR=4.889)是影响WD患者心理状况的独立相关因素。结论:减轻神经功能损害并恢复神经功能可能是改善WD患者心理状况根本的途径。

Objective：To study the related factors affecting mental health of patients with wilson disease （ WD） .Methods：We used Eysenck Personality Questionnaire （ EPQ ） , Unified Wilson＇s Disease Rating Scale （ UWDRS ） , Nazer Scale , Social Support Rating Scale（SSRS） and Symptom Checklist 90 （Scl-90） to investigate 82 patients with WD and recorded their basic clinical data as well as head imaging changes .The factors which may affact its mental health were analyzed .Results：The prevalence rates of psychological dis-order of the patients with WD was 46.3%.Their mental health was related to the neuroticism , degree of neurologic lesion , degree of liver lesion, social support and imaging range of intracranial lesions .Neurologic lesion（OR=8.708） and imaging range of intracranial lesions （OR=4.889） were independent Ly related factors in multiariable Logistic regression analysis .Conclusion：To reduce the neu-rologic lesion and restore the function of neurologic can improve the mental health of patient with WD .