喉癌组织S-100蛋白的检测

Detection of S-100 protein in laryngeal carcinoma

目的 :探讨 S- 10 0蛋白检测与喉癌的生物学行为及预后的关系。方法 :采用免疫组化方法以抗 S- 10 0蛋白抗体标记 6 8例喉癌组织和 2 1例非喉癌组织中 S- 10 0蛋白阳性细胞。结果 :6 8例喉癌组织中 S- 10 0蛋白细胞阳性检出率为 6 3.2 4% ,主要散在于肿瘤细胞间和间质中 ,非喉癌组织中很少见到 S- 10 0蛋白细胞阳性 ,它的分布情况与喉癌预后有关 ;S- 10 0蛋白阳性者术后 5年生存率 (6 8.73% )明显高于阴性者 (39.32 % ) ,P <0 .0 5。结论 :喉癌组织中出现 S- 10 0蛋白阳性细胞者预后好 ,在临床上 ,S- 10 0蛋白细胞的检测对判断喉癌预后有一定参考价值。

Objective:To study the relationship between S 100 protein and prognosis of laryngeal carcinoma.Method:S 100 protein was observed by immunohistochemical methods using anti S 100 protein antibody in 68 laryngeal carcinoma and 21 non cancer laryngeal tissues.Result:The result showed that S 100 protein positive were found 43( 63.24 %)in 68 laryngeal carcinoma.S 100 protein positive cells were interspersed among the tumor cells and in the stroma.S 100 protein were rare in non cancer laryngeal tissues.The five year survival rate in patients with S 100 protein positive was significantly higher than that in patients with S 100 protein negative.Conclusion:Our result indicated that the detection of S 100 protein is of value for the prognostic analysis in patients with laryngeal carcinoma.