老年性骨质疏松和瘦素的相关性研究进展

The correlation research progress between leptin and senile osteoporosis

骨质疏松(osteoporosis,OP)是一种以骨量减少,骨的微细结构破坏为特征的全身代谢性骨骼疾病。瘦素(Leptin,Lep)是由脂肪细胞分泌的一种肽类激素,对骨量正面和负面都有影响,并对骨代谢发挥调节作用。在体外,Lep可调节成骨细胞的增殖,抑制成骨细胞依赖的破骨细胞的重吸收;在体内主要是负面作用,Lep抑制脑干中5-羟色胺(5-hydroxy tryptamine,5-ht)的合成,增加交感神经信号由下丘脑到骨的输出。但临床试验中关于Lep与老年性OP之间的相关性和Lep在中枢神经系统、外周组织中的作用及存在的问题尚未明确,文中就Lep与老年性OP的相关性最新研究进展作一综述。

Osteoporosis is a kind of systemic metabolic bone diseases,characterized by bone loss,bone subtle structural damage.Leptin is a peptide hormone which secreted by fat cells,that has both positive and negative effects to the bone,and plays a role of regulating on bone metabolism.In vitro,Leptin can regulate proliferation of osteoblast and inhibit reabsorption of osteoblasts depend on osteoclast.In vivo,Leptin can inhibit the synthesis of serotonin in the brain stem and increase the sympathetic nerve signals output by the hypothalamus to the bone,it mainly has a negative effect.But clinical trials about the correlation between Leptin and senile osteoporosis,the role of Leptin in the central nervous system and peripheral tissue problems are still unclear.In this paper,we will make a comprehensive overview about the latest research progress in the correlation between leptin and senile osteoporosis.