25-OH-D_2、25-OH-D_3与股骨颈骨密度的相关性研究

Correlation study between 25-OH-D_2,25-OH-D_3,and the bone mineral density of the femoral neck

目的研究人体内25羟维生素D2(25-OH-D2)、25羟维生素D3(25-OH-D3)含量与股骨颈骨密度的相关性。方法利用双能X线骨密度测量法检测205例患者股骨颈骨密度,同时用高效液相色谱法检测其血清中25-OH-D2及25-OH-D3的含量,并根据维生素D(VitD)含量分析VitD与骨密度的关系。结果人体内VitD(25-OH-D2+25-OH-D3)含量与50岁以下者的股骨颈骨矿含量无相关性(P>0.05),与50岁以上者呈正向直线相关(P<0.05或P<0.01),男女性别均一致。结论对于50岁以上者,随着年龄的增长,其体内血清VitD的含量降低很可能会导致其股骨颈骨矿含量下降。

Objective To investigate the correlation between the content of the 25-hydroxyvitamin D2 （ 25-（ OH ） D2 ） and 25-hydroxyvitamin （25-（OH）D3） and the bone mineral density of the femoral neck （femoral neck BMD）.Methods The femoral neck BMD of 205 patients was detected using dual energy X-ray absorptiometry.The serum levels of 25-（ OH） D2 and 25-（ OH） D3 were determined using high performance liquid chromatography.The correlation between Vitamin D （ Vit D） content and the femoral neck BMD was analyzed.Results In patients younger than 50 years old, no correlation between the VitD （25-（OH）D2 and 25-（OH）D3） content and the femoral neck BMD was observed （P〉0.05）.But in patients elder than 50 years old, a positive linear correlation was observed （P〈0.05 or P〈0.01）.This existed both in men and women.Conclusion In patients elder than 50 years old, the serum Vit D level decreases along with the increase of age, which may cause a decline in the femoral neck BMD.