基于V-ATPase a3转运蛋白探讨骨质疏松症的分子机制

Exploration of the molecular mechanism of osteoporosis based on the V-ATPase a3 transporter

目的存在于破骨细胞的皱褶缘上的V-ATPase a3转运蛋白在骨质疏松症的骨吸收中发挥着重要作用。V-ATPase a3转运蛋白将H+逆浓度梯度转运到密闭区,溶解无机矿物质,为水解酶如CAⅡ、CATK、MMPs等提供酸性环境,抑制V-ATPase a3转运蛋白已成为治疗骨质疏松症的新靶标;并深化对CAⅡ、CATK、MMPs等水解酶阻滞剂的认识,从而多渠道、多方位、多靶点地拓展骨质疏松症的治疗。

V-ATPase a3 transporter, which exists in the ruffled border of osteoclasts, plays an important role in bone resorption in osteoporosis.It can transport H＋to the closed area to form a high H＋concentration zone, thus dissolving inorganic minerals and providing an acidic environment for hydrolytic enzymes including CA II, CATK, and MMPs.The inhibitor of the V-ATPase a3 transporter has become the new target for the treatment of osteoporosis.Deep understanding of the hydrolytic enzymes including CA II, CATK, and MMPs can provide new ideas concerning the multi-channel, multi-dimension, and multi-target treatment of the osteoporosis.