脾不统血证中脾气虚状态与出血因素关系的研究

Study on Relationship between Insufficiency of Spleen-Qi and Bleeding Factor in Pibu Tongxue Zheng

目的 :探讨同一出血因素作用于脾气虚动物和非脾气虚动物时对出、凝血过程中某些具体环节的影响 ,及益气止血中药在其中的纠正作用。方法 :采用单纯水蛭、番泻叶加游泳及三种因素复合作用塑造了三种动物模型 ,并予以最后一种动物模型益气止血中药治疗 ,在此基础上测定了PT、CT、FIB及Ca2 +。结果 :各模型组大鼠均有出血倾向 ,而以复合因素作用组最为显著。结论 :在脾气虚过程中机体的凝血和纤溶系统即受到一定程度的影响 ,而此时 (脾气虚状态 )对于出血因素 (水蛭粉 )更加敏感 ,而自拟益气止血剂对此状态有良好纠正作用。

Objective: Approach on bleeding and coagulation effect in some concretely segments when identical bleeding factor was used in insufficiency of Spleen-Qi and non-insufficiency of Spleen-Qi animals. Moreover, observing Yiqi Zhixue Chinese drugs use of correction.Methods: Mading three animal models through simple leech、senna leaf with swimming and three compound factors. Giving the final model treatment by Yiqi Zhixue Chinese drugs. Then detecting PT、CT、FIB and Ca2+ .Results: Each model Rat had bleeding tendency. But compound group was the most outstaoding. Conclusion: Coagulation and fibrinolytic system of organism were certainly effected by insufficiency of Spleen-Qi. Organism was more sensitive for bleeding factor (leech power) when Spleen-Qi was insufficiency. However, Yiqi Zhixue dose made by oneself had good correction use to this state.