抗甲状腺药物对Graves病患者心率变异性的影响

Effect of Anti-Thyroid Drug on Heart Rate Variation in Patients with Graves Disease

目的:探讨抗甲状腺药物(ATD)对毒性弥漫性甲状腺肿即Graves病(GD)患者治疗前后心率变异性(HRV)的影响。方法:分别测定30例正常人及24例GD患者ATD治疗前后的HRV。结果:GD患者治疗前(组Ⅰ)所致自主神经病变(AN)的发生率约为83.3％,病情控制后(组Ⅱ)的发生率约为12.5％。与健康对照组相比较,组Ⅰ的总功率、超低频段功率、高频段功率和平衡参数数值具有显著性差异,而与组Ⅱ的差异无显著性。结论:治疗前的GD患者可能存在心自主神经系统功能(ANSF)的全面减损,病情控制后明显恢复,这些改变推测与血液中的甲状腺激素对心自主神经的兴奋性刺激有关。

To study the effect of anti-thyroid drug(ATD)on heart rate variation (HRV)in patients with Graves disease (GD). Methods: The HRV of 24 patients with GD was compared with that of 30 normal subjects and the effects of ATD on HRV of the patients were also evaluated. Results: The prevalence of autonomic neuropathy (AN)in GD before treatment (group I) was about 83.3 % and it was about 12.5 % after treatment (group II). There were significant differences of spectral index(TFP,PHV,PW and RVH)between the group I and the control group,and there was no significant difference between the group II and the control group. Conclusion: It was possible that the complete damage of autonomic nervous system function occurred in GD patients before treatment,but the patients obviously recovered after treatment. These changes might be correlated with the thyroid hormone in blood which stimulated the cardiac autonomic nerves.