大黄蛰虫丸联合异维A酸治疗重度痤疮疗效观察

Clinical efficacy of Dahuangzhechong pill combining with Isotretinoin in the treatment of severe acne

目的:探讨大黄蛰虫丸联合异维A酸治疗重度痤疮的疗效及安全性。方法:将入选的130例患者分为治疗组和对照组。两组患者均口服异维A酸胶囊,每日2次,每次10mg;外用夫西地酸软膏,每日2次。治疗组同时加用大黄蛰虫丸,每次3g,每日3次。疗程8周。结果:两组有效率分别为80.6%和53.99%,疗效比较有显著性差异(P<0.05)。结论:大黄蛰虫丸联合异维A酸治疗重度痤疮,疗效高,治疗时间短,且不良反应较少,值得临床推广应用。

Objective To investigate the efficacy and safety of Dahuang Zhechong Pill combined with isotretinoin in the treatment of severe ache. Methods 130 cases were divided into 2 groups, both of the groups were given oral isotretinoin capsule, put the drops in twice a day, each time 10mg; topical fusidic acid cream rub,twice a day. The treatment group were treated with Dahuangzhechong pill at the same time,each time 3g,3 times a day, the course of the treatment was 8 weeks. Results The efficiency of the two groups were 80.6% and 53.99%,and the difference was statistically significant（P〈 0.05）. Conclusion Dahuang Zhechong Pill combined with isotretinoin in the treatment of severe acne not only improves the curative effect, but also shortens the treatment time with less adverse reactions, so it is worth promoting in clinic.