四种用于足月妊娠促宫颈成熟方法的比较研究

Cervical Ripening in Women at Term with Four Methods

目的:探讨目前常用的各种促宫颈成熟方法在足月妊娠促宫颈成熟及引产中的作用。方法:选择有引产指征的足月妊娠妇女210例,随机分为米非司酮组(A)、蒂洛安组(B)、催产素组(C)、米索前列醇组(D)及空白对照组(E),观察各组促宫颈成熟及引产效果。结果:米非司酮组宫颈评分增高为(3.39±0.87)分,高于其他各组。各种配伍组中,米非司酮配伍米索前列醇或催产素的引产成功率高于其他组。结论:米非司酮有显著的促宫颈成熟的作用,米索前列醇及催产素有显著的刺激宫缩作用,米非司酮配伍米索或催产素在足月妊娠促宫颈成熟和引产过程中为非常有效的方案。

To determine the efficacy of 4 cervical ripening and labor induction methods in women at term. Methods: Two hundred and ten women who had clinical indications for labor induction were randomly allocated into 5 groups: mife-pristone(A) ,Diluoan(B) ,oxytocin(C) ,misoprostol(D)and control(E)groups. ResultsrThe cervical Bishop score in group A was increased to 3.39 ± 0.87 and higher than those in other groups ( P < 0.05 ). The success rates of labor induction and vaginal delivery in mifepristone combined with misoprostol or oxytocin were significantly higher than those in other groups (P<0.05). Conclusion: Mifepristone is an effective inductive agent for cervical ripening, misoprostol and oxytocin were strong uterine contract revulsivum. Mifepristone combined with misoprostol or oxytocin was considered as the best way of labor induction in term pregnancy.