大型综合性医院524株细菌的分离鉴定及耐药性调查

Distribution of Isolated Flora and Flora Resistant Characters in General Hospital

目的:调查综合医院常用菌株对各种常用抗生素耐药率的状况,为合理使用抗菌素控制感染提供依据。方法:应用WHONET-4软件对临床分离菌的药敏结果进行统计分析。结果:分离菌株前六位依次为大肠埃希氏菌、铜绿假单胞菌、金黄色葡萄球菌、凝固酶阴性葡萄球菌、肠球菌、肺炎克雷伯氏菌。检测它们对13种抗生素的耐药性。结果显示革兰氏阳性球菌除肠球菌对万古霉素耐药率有所上升(9.1％),未见有耐万古霉素的葡萄球菌株出现。革兰氏阴性杆菌(包括铜绿假单胞菌)仍对泰能、头孢他啶、丁胺卡那最为敏感。耐苯唑西林的葡萄球菌对绝大多数抗生素耐药率均在50％以上。大肠埃希氏菌对环丙沙星的耐药率直线上升,已达63.9％。结论:定期系统的耐药监测对临床合理用药十分必要。

To study the distribution of isolated flora and flora resistant characters in general hospital so as to provide basis in respect of reasonable application of antibiotics. Methods: The results of antibiotic sensitive test were analyzed with WHONET-4 software in personal microcomputer. Results: The first 6 kinds of isolated bacteria flora arrangement were Eschorichia coli,Pseudomonas,Staphylococcus aureus,Staphylococcus apiolermis,Enterococcus faecalis and Klebsiella pneu-moniae in order of precedence respectively. Their resistant characters for 13 kinds of antibiotics were investigated. The results indicated that G~ bacteria flora was more sensitive to IMP,CAZ and AMK. The resistant rate of staphylococcus flora for OXA was above 50 percent, and that of Eschorichia coli for CIP increased sharply (63.9 % ). Conclusion: A regular and systematic monitor of bacteria resistance is very important for reasonable clinical application of antibiotics.