智能多肽的自组装机理及其生物学应用

Self-assembly Mechanism and Biological Applications of Smart Peptides

智能多肽是指智能响应外界刺激并做出相应回应的多肽。由于其形成过程为自发的自组装,故智能多肽又可称为自组装多肽。智能多肽的氨基酸构成使其拥有良好的生物相容性及生物可降解性,作为构筑基元拼接成为功能性材料,在新型生物材料方面展示出了广阔的应用前景。概括了智能多肽的性质、自组装机理及应用,重点阐述了它在生物能源、生物医学工程和分离工程上的应用,以期在系统认识智能多肽的基础上,发掘其应用潜能,突破开发瓶颈。

Stimuli-responsive peptides are referred as smart ＂ peptides capable of self-assembling into supramolecular structures that are responsive to environment changes. Such kinds of smart peptides can self- assemble spontaneously, so they are also called self-assembling peptides. Based on their property, smart peptides can be used as building blocks to construct materials possessing different conformations and biological functions. In this review, we presented the self-assembly mechanism of smart peptides, with a focus on the great potentials of smart peptides in many biological fields, such as biomedical engineering, as well as in energy applications, and bioseparation engineering.