摘要
目的探讨寻常性银屑病患者皮损组织中辅助性T细胞17(T helper cell 17,Th17)转录因子RoRγt和细胞因子IL-17以及调节性T细胞(regulatory T cell,Treg)转录因子Foxp3和细胞因子IL-10的表达水平。方法采用免疫组织化学法检测50例寻常性银屑病(进行期)患者皮损、25例正常人皮肤(包皮)组织中:RORγt,IL-17,Foxp3和IL-10的水平。结果 RORγt,IL-17在寻常性银屑病患者皮损组织中的表达显著高于正常皮肤组织,差异有统计学意义(P<0.05);Foxp3,IL-10在寻常性银屑病患者皮损组织中的表达显著低于正常皮肤组织,差异有统计学意义(P<0.05)。结论寻常性银屑病患者皮损组织中RORγt,IL-17表达显著增高;Foxp3,IL-10表达显著降低。其局部组织中可能存在Th17/Treg细胞失衡,并在银屑病的发病过程中起着一定的作用。
Objective To detect the expressions of T helper cell 17 (Thl7) transcription factor RORγt, cytokine IL-17 and regulatory T cells (Treg) transcription factor Foxp3, cytokine IL-10 in the lesions of patients with psoria- sis vulgaris. Methods Immunohistochemistry method was applied to detect the expressions of RORγt cyto- kine IL-17, Foxp3 and cytokine IL-IO in 50 cases lesions of patients with acute psoriasis vulgaris and 25 cases of normal skin (foreskin) organization. Results The expressions of RORγt and IL-17 in the lesions of patients with psoriasis vulgaris were significantly higher than in normal skin tissue ( P 〈 0.05 ) ; The expres- sions of Foxp3 and IL-IO in the lesions of patients with psoriasis vulgaris were significantly lower than the normal skin tissue (P 〈 0.05). Conclusion In the lesions of patients with psoriasis vulgaris : the expres- sions of RORγt, IL-17 were significantly higher; the expressions of Foxp3, IL-IO were significantly lower. Th17 cells and Treg cells may be imbalanced in the lesions of the patients with psoriasis vulgaris.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第7期681-683,689,共4页
The Chinese Journal of Dermatovenereology