强力霉素对兔颞颌关节病模型的治疗作用

Therapeutical Effects of Doxycycline on Rabbit Temporomandibular Arthritis

目的研究强力霉素对颞颌关节病的治疗作用。方法 36只新西兰大白兔随机分为对照组和实验组,应用胶原酶注射法制备36例兔颞颌关节病模型。实验组在胶原酶注射的次日起每天给予口服强力霉素,对照组口服安慰剂。在第4,8和12周末每组分别处死6只大白兔,分别在光镜、电镜下观察关节软骨和关节盘的病理变化。结果 4周末,对照组关节软骨变薄,血管增生明显,实验组只表现轻微病变;8周末,对照组病变更为明显,关节软骨面出现裂隙,血管增生更为明显,实验组可见病损的修复;12周末时,对照组关节软骨病理改变严重,出现严重剥脱,骨质象牙化,实验组病损修复趋于正常。结论强力霉素可以促进颞颌关节的自身修复,抑制颞颌关节病的发展,对颞颌关节病早期治疗有显著作用。

Objective To investigate the therapeutical effect of doxycycline for temporomandibular arthritis .Methods Thirty-six New Zealand white rabbits were randomly divided into control group and experimental group .Thirty-six models of temporomandibular arthritis in rabbits were prepared by injection of collagenase .Doxycycline was given orally from the next day after the injection of collagenase for the experimental group and the placebo was given orally for the control group .Each group separately executed six big white rabbit by the end of 4th,8th and 12th week.The pathological changes of articular cartilage and joint plate were observed respectively under light microscope ,elec-tron microscope.Results By the end of 4th week,samples of the control group showed the cartilage became thin ,and blood vessel growth was obvious.By the end of 8th week,osteoarthritis pathological changes were more apparent .By the end of 12th week,samples of the control group pathological changes of articular cartilage were completely damaged .No pathological changes were found in the treatment group .Conclusion The results suggest that doxycycline can promote temporomandibular joint repair ,and inhibite the development of temporomandibular arthritis . Doxycycline has a significant effect on temporal jaw joint in the early treatment .