2012年河北与天津静海县接壤地区健康人群脊髓灰质炎中和抗体水平调查

Neutralized Antibody Levels of Poliomyelitis in Healthy Population of Hebei in 2012

目的了解与2012年发现疫苗衍生脊髓灰质炎（脊灰）病毒（VDPV）病例的天津市静海县接壤的河北省4个县健康人群脊髓灰质炎（脊灰）免疫状况,为评估脊灰野病毒输入及疫苗衍生脊灰病毒循环发生提供科学依据。方法调查该4个县〈1岁、1~2岁、3~4岁、5~6岁、7~10岁、11~14岁、15~19岁、≥20岁8个年龄组共465人,采用微量细胞中和实验测定脊灰中和抗体。结果调查人群脊灰中和抗体Ⅰ、Ⅱ、Ⅲ型阳性率分别是97.2%、98.5%和92.7%;抗体滴度中位数分别是1∶128、1∶128和1∶64。结论与天津市静海县接壤的4县健康人群对脊灰病毒形成了良好的免疫屏障。

Objective To investigate poliomyelitis antibody levels among healthy population in Hebei and to provide scientific basis for eliminating the disease.Methods Altogether 465 serum samples were collected in 4 counties of Hebei and microplate neutralization test was employed to determine antibody the levels.Results The positive rates of poliomyelitis antibody were respectively 97.2%,98.5% and 92.7%;antibody titer median for polio type Ⅰ,Ⅱ and Ⅲ were respectively 1：128,1：128 and 1：64.Conclusion The healthy population in the four counties of Hebei has formed qualified immunologic barrier towards poliomyelitis virus.