某院细菌耐药率与抗菌药物用药频度相关性分析

Research on Correlation between Application of Antibacterial Agents and Bacterial Resistance

目的:分析细菌耐药率与抗菌药物用药频度的相关关系,为临床合理选用抗菌药物提供依据。方法:采用K-B法进行药敏检测,按美国临床和实验室标准化协会(CLSI)标准分析结果;采用用药频度分析法对本院近3年抗菌药物消耗量进行统计及排序;采用SPSS分析软件进行细菌耐药率与抗菌药物用药频度相关性分析。结果:3年抗菌药物用药频度平均下降率为21.23%;肺炎克雷伯菌对左氧氟沙星耐药率随左氧氟沙星用药频度升高呈上升趋势,而铜绿假单胞菌对环丙沙星的耐药率随环丙沙星用用药频度下降呈降低趋势。结论:细菌耐药率与抗菌药物用药频度变化趋势存在一定的内在联系,规范抗菌药物的临床合理应用可能减缓细菌的耐药趋势。

Objective： to analyze the relationship between bacterial resistance and DDDs of antibacterial agents, so as to provide reference for the rational clinical application of antibiotics. Methods： The bacteria were isolated and identified, and the susceptibility was tested by Kirby Bauer. The results were interpreted in accordance with Clinical and Laboratory Standards Institute. The method of DDD system was used to analysis the consumption of antibiotic medicine of the hospital during the last 3 years. SPSS were used to analysis the relationship between bacterial resistance and DDDs of antibacterial agents. Results： The average annual decline rate of the total DDDs of antibiotics was 21.23% during the three years. Klebsiella pneumoniae to levofloxacin resistant rate increased with the increase of levofloxacin ddds. Pseudomonas aeruginosa to eiprofloxaein resistant rate decreased with the decrease of eiprofloxaein DDDs. Conclusions： Drug resistance of bacteria is related to DDDs of antibiotics in hospital. Standardization of clinical rational application of antibiotics may slow down bacterial resistance trends.