天芪平颤方治疗帕金森病运动症状临床观察

Clinical Observation of Tianqi Pingchan Formula in Treatment of Motor Symptoms of Parkinson's Disease

目的:观察天芪平颤方化裁结合西药治疗帕金森(PD)的临床疗效。方法:98例患者随机分为验证组(49例)、对照组(49例),两组均常规服用西药,验证组加裁本方(服药3个月—停药1个月—服药3个月),共随访7个月,评估治疗前后UPDRS(I、II、III)评分、PIMS评分、中医证候等参数变化。结果:7个月随访时验证组UPDRS评分有改善,验证组用药后对运动症状的改善幅度较对照组优(P<0.05);PIMS评分,中医证候积分均有明显改善(P<0.05);7个月随访时,2组多巴等效剂量都有增加,但验证组左旋多巴等效剂量的升高明显低于对照组(P<0.05)。结论:天芪平颤方对PD运动症状有协助改善作用;天芪平颤方对PD运动患者生活质量有较好改善作用。

Ohjective ： To observe the effect of Tianqi Pingchan Formula on treatment of PD non-motor symptoms. Methods ： PD patients were randomly divided into test group （ 49 cases ） and control group （ 49 cases ）. The test group was treated by Tianqi Pingehan Formula combined with conventional western medicine （ taken 3 months., stop 1 month, taken 3 months ）. Te unified PD Rating Scale （ UPDRS ）, PD- NMSQuest, PIMS assessment parameters were used in baseline,3-month and 7-month follow up. Result： The scores of UPDRS could improve in 7-month follow up, but the motor symptoms of the test group significantly improved compared with that of the control group （ P〈0.05 ）. The scores of PIMS improved in the test group in 7-month follow up compared with baseline. The daily L-dopa equivalent dosage of two groups in 7-month follow up was washigher than that in the baseline, hut elevated dose in test group was significantly lower than that the control group （P〈0.05）. Conclusion： Tianqi Pingchan Formula has possible effect on motor symptoms of PD and can help to improve the quality of life in patients with PD.