盐酸氯卡色林消旋体的合成工艺改进

Improvement the Synthesis Process of Lorcaserin Hydrochloride Racemate

改进盐酸氯卡色林消旋体的合成工艺,以对氯苯乙腈为起始原料,经还原得到中间体对氯苯乙胺,与2-氯丙酰氯反应,再经傅克烷基化反应成环,然后使用硼氢化钠、三氯化铝还原体系还原酰胺,最后成盐,得到目标产物,总收率达25.0%。

This study is to synthesize lorcaserin hydrochloride racemate and improve the process. The 4-chlorophenethylamine was synthesized from 4-chlorobenzyl cyanide by reduction, and then it was reacted with 2-chloropropionyl chloride, through cyclization, reduction by sodium borohydride and aluminum chloride,finally through salt formation, to form lorcaserin hydrochloride racemate, with an overall yield of 25.0%.