胃癌组织中E-cadherin和MMP-9的表达及其临床意义

The Expression and Significance of E- cadherin and MMP- 9 in Gastric Carcinoma

目的探讨E-cadherin和MMP-9在胃癌组织中的表达,分析二者的相关性、与临床病理特征的关系及它们在胃癌浸润转移过程中的作用。方法用免疫组织化学染色方法分别检测E-cadherin和MMP-9在30例胃癌组织中及25例正常胃粘膜内的表达情况。结果 E-cadherin在胃癌组织中和正常胃粘膜中阳性表达率分别为33.33%(10/30)和100%(25/25)。MMP-9在胃癌组织中和正常胃粘膜中阳性表达率分别为76.7%(23/30)和0.00%(0/25),胃癌组织中E-cadherin和MMP-9表达呈负相关(P<0.05)。结论胃癌组织E-cadherin的表达低而MMP-9的表达高,说明两者与胃癌的生物学行为密切相关,二者共同促进了胃癌的浸润与转移,因此,E-cadherin和MMP-9检测有助于胃癌恶性程度和侵袭能力的判断。

Objective To investigate the expression and significance of e-cadherin and MMP-9 in Gastric carcinoma and to analyze the relationship between them and tumor Clinicopathological features as well as the role of E-cadherin and MMP-9 in the metastasis and invasion.Methods Immunohisto chemistry staining （S-Pmethod） was used to detect the expression of E-cadherin and MMP-9 in 30 cases of gastric cancer and 25 cases of normal gastric mucosa.Results The positive expression rate of E-cadherin in gastric cancer,and normal tissues was 33.33 ％ （10/30）and 100％ （25/25）.The positive expression rate of MMP-9 in gastric cancer and normal tissues was 76.7％ （23/30） and 0.00％ （0/25）.E-cadherin expression was negatively correlated with MMP-9.Conclusion The expression of E-cadherin and MMP-9 are closely correlated with the biological behavior of gastric carcinoma.They may play a crucial role in gastric cancer invasion and metastasis.E-cadherin and MMP-9 may be helpful to evaluate the capability of the tumor invasion and diversion of gastric carcinoma.