血清CA-125水平和非致命性心肌梗塞关系的初步探讨

Relationship between serum levels of carbohydrate antigen 125 levels and non fatal myocardial infarction in senile patients

目的就血清中CA-125的水平和人群非致命性心肌梗塞(MI)发生风险的关系作初步探讨。方法收集210例十堰市东风汽车公司离退休职工中患有非致命性MI者为病例组;另从同样的人群中不患非致命性MI及相关疾病的退休职工中随机抽取1 050例作为对照组。分别抽血检测其血清CA-125水平,同时收集体检资料及治疗情况。定量资料分析采用t检验,组间率、分类资料的分析比较采用χ2检验,血清CA-125及其他危险因素与MI的关系采用多元Logistic回归分析方法进行分析。结果病例组血清CA-125水平明显高于对照组(P<0.01)。并且随着血清CA-125水平的增高,患非致命性心肌梗塞的风险也随之升高,呈线性关系。高年龄组(≥65岁)、女性、BMI正常者、有高血压和糖尿病家族史的人群中,CA125水平高者其患非致死性MI的风险更高。结论中老年人群的血清CA-125水平越高,其患非致命性MI的风险也可能越高。CA-125可能是一个与非致命性MI相关的新的生物学标志物,但其具体机制有待于进一步的研究阐明。

Objective To investigate the relationship between the serum level of carbohydrate antigen 125 （CA-125） and non-fatal myocardial infarction （MI） risk in senile patients. Methods The 210 diagnosed non-fatal MI patients and 1050 retirees without MI and MI-related diseases were selected as controls. Serum levels of CA-125 were measured, baseline information and medication history were collected. Continuous variables were analyzed by 2-tailed t tests, Categorical data were evaluated by Chi-square test. Logistic regression was used to analysze the association between serum CA-125 and the risk of non-fatal MI. Results Serum levels of CA- 125 were significantly higher in case group than controls （P 〈 0.01 ）. The MI risk increased with the level of CA-125 in a dose-response manner. Furthermore, CA-125 level-associated MI risks were higher in subjects aged over 65 years, females, normal BMI and subjects with a family history of diabetes and hypertension. Conclusions Elevated serum level of CA-125 might be associated with increased risk of non-fatal myocardial infarction in senile population. Serum CA-125 might be a new biomarker for non-fatal MI. The detailed mechanisms requires further investigations.