重症手足口病合并脑炎患者药物治疗效果分析

Effect of drug medication on hand-foot-mouth disease patients complicated with encephalitis

目的探索治疗手足口病合并脑炎患者的有效治疗方案与效果，促进临床合理用药，保证患者用药安全。方法收集汕头市中心医院2013年1～12月手足口病合并脑炎确诊患儿电子病历56例，对其用药情况进行统计分析。结果治疗手足口病合并脑炎的抗病毒药物主要是蓝芩口服液、喜炎平注射液（或痰热清注射液）以及利巴韦林注射液。口服中成药、中药注射液与抗病毒西药三者联合使用率达到100％。抗菌药物使用率达87．5％，以头孢呋辛为主，存在一定的滥用现象。100％的患儿使用大剂量甲基强的松龙联合静脉注射免疫球蛋白治疗。结论手足口病合并脑炎在治疗上基本遵循卫生部《手足口病诊疗指南》。但仍存在一定的不合理用药现象，主要体现在大范围用药、重复用药、无指症使用抗菌药物等。

Objective To explore the effect of drug medication on hand-foot-mouth disease （HFMD） cases complicated with encephalitis, improve the level of clinical use of drugs and ensure the medication safety. Methods The data of medication on 56 HFMD patients complicated with encephalitis from January to December in 2013 were analyzed. Results The drug of Lanqin oral solution, Xiyanping injection （or Tanreqing injection） and Ribavirin injection were used for treatment of HFMD eases complicated with encephalitis.The combined usage rate of oral Chinese medicine, Chinese medicine injection with antiviral medicine was 100%. The usage rate of antimicrobial agents was 87.5%, most with eefuroxime, might involved with drug abuse. 100% of the patients received high-dose methylprednisolone and intravenous immunoglobulin therapy with good results. Conclusions The treatment of HFMD cases complicated with encephalitis basically follows the Ministry of Health ＂Hand-foot-mouth disease diagnosis and treatment guidelines＂. But there still existed irrational use of drugs, mainly in the excessive medication, repeated drug use, no indication of using antibiotics, resulting in a waste of medical resources and increasing the economic burden of patients.