VEGF、组织因子及D-二聚体与肺癌关系的研究(英文)

Research on the Relationship among VEGF,Tissue Factor,D-Dimer and Lung Cancer

目的:探讨肺癌患者血浆VEGF、组织因子及D-二聚体水平与并发静脉血栓的关系及其相关性。方法:收集2013年3月至2013年9月,青岛大学附属医院收治的初诊肺癌患者83例为肺癌组,肺癌并静脉栓塞组11例,健康体检组80例,应用酶联免疫吸附(ELISA)法测定VEGF、TF、D-二聚体的水平并进行比较分析。结果:肺癌组和肺癌并静脉栓塞组血浆VEGF、TF及D-二聚体水平均高于健康对照组,肺癌并静脉栓塞组血浆VEGF、TF及D-二聚体水平高于肺癌组,VEGF与TF及D-二聚体的表达呈正相关。结论:VEGF、TF及D-二聚体是肺癌患者并发静脉血栓的重要标志物,可通过测定其在肺癌患者血浆中的水平来推测并发静脉血栓的危险性,以针对性应用抗凝治疗。

Objective： To investigate the relationship among boold levels of vascular endothelial growth factor （VEGF）, tissue factor （TF）, D-Dimer and thromboembolic events in patients with lung cancer. Methods： From March to September 2013, 83 cases of the first diagnosis lung cancer patients of the affiliated hospital of Qingdao University were collected as lung cancer group, 11 lung cancer patients accompanied with venous thromboembolism （VTE） as lung cancer with VTE group and 80 normal healthy as controls. VEGF, TF and D-Dimer levels in serum were detected by enzyme-linked immunosorbent assay （ELISA）. The correlation among VEGF, TF, D-Dimer and lung cancer was analyzed. Results： VEGF, TF and D-Dimer levels in serum of lung cancer group and lung cancer with VTE group were significantly higher than that in normal control group （P〈0.05）. VEGF, TF and D-Dimer levels of lung cancer with VTE group were observably higher than that in lung cancer group （P 〈0.05）. The expression of VEGF and TF and D-Dimer was positively correlation in lung cancer with VTE patients. Conclusions： VEGF, TF and D-Dimer are important marks of lung cancer patients accompanied with thromboembolism events. The risk of venous thrombosis of lung cancer patients can be evaluated by measuring the levels ofVEGF, TF and D-Dimer, in order to applicate anticoagulant therapy pertinently.